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The adventure begins when the loving owners of three irresistible pets (Chance, a fun-loving American bulldog pup; Sassy, a hilarious Himalayan cat who lives up to her name; and Shadow, a wise old golden retriever) are forced to leave them in the temporary care of a friend who lives hundreds of miles away. But after several days, the worried animals begin to their family must be in trouble, so they decide to head for home. On their incredible journey across the ruggedly beautiful Sierras, they encounter unexpected surprises from man, beast, and nature alike.

消失螢光幕多年的梁細妹，原來早已退休，在家含飴弄孫。大兒子Robert十年如一日的不務實，常幻想能一步登天，使梁細妹把自己的希望完全寄託在小兒子Albert身上而對他疼愛有加。此舉卻讓Robert認為母親偏心，誓言一定要發大財來換取母親對自己的重視。機緣巧合之下，Robert獲得一尊財神婆的玩偶公仔，財神婆更現出真身與他交流，希望他能以正道獲取財富。Robert自以為財運已到而不斷的想依靠邪門歪道試圖一夜致富。囂張的行徑，招致了破財神出現，令Robert陷入萬劫不復的局面，抵押房子以及高利貸借來的款項，一夜之間化為烏有。這次真的是…傷腦筋哦！

赫力昂携手顶尖高校，推动疼痛研究新突破