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中国西南、与世隔绝、群山环抱中有个寨子，是个人皆长寿、规矩自成之地，清时皇帝赐名“长寿镇”。某日突爆传染病，地方官派医生（任达华 饰）前往诊治，他在镇子外发现奄奄一息的牛结实（黄渤 饰）。进寨后，往日温厚的村民一反常态，不仅对牛结实拒施援手、避若瘟疫，更迁怒于医生多 管闲事，老镇长（马精武 饰）亲自带着长寿镇医生（苏有朋 饰）和接生婆（梁静 饰）、油漆匠，老族长等人千万百计的阻挠医生对牛结实的救援，牛结实最终没能被救活，医生也找不到此人暴毙的原因。镇民们对医生的不欢迎不合作态度，令医生很沮丧，正当他准备离开的时候，无意中发现了一个被全镇民众一起隐藏在山崖上的一个秘密，带着重重疑惑医生决定暗中走访长寿镇，直到他偶遇一个男孩，长寿镇迷案的真相才一步步揭开…… 该片改编自陈铁军的中篇小说《儿戏杀人》。
A group of tired commuters have caught the last train home, ready to hop into their beds for the night. However, their train soon veers off-course and crashes into an abandoned tunnel. The three surviving commuters; withdrawn mother Yi Ling, her son Lucas, and student Janice, are forced to band together and survive the night, as well as avoid the mysterious monster hunting them. Yi Ling still suffers from flashbacks to the car accident that killed her husband and nearly took Lucas` life too. When Lucas is snatched away by the monster, her maternal instincts are tested, and Janice`s ideas of family are challenged as she remembers her difficult relationship with her estranged father. Back at the subway control headquarters, the engineers do their best to make sense of the situation and rescue the survivors.
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