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本片根据纽约市的英籍神经医师奥利佛·萨克斯（Oliver Sacks）的同名回忆录改编。1969年，羞怯内向但对实验充满热忱的脑科医生马尔科姆·塞尔（罗宾·威廉姆斯 Robin Williams 饰）来到纽约市布朗克斯区一家医院，对院内的强直性昏厥证患者进行治疗。在护士埃莉诺（朱莉·卡夫娜 Julie Kavner 饰）的帮助和鼓励下，塞尔医生对病人大胆用药，使一群昏厥几十年的患者重获新生，尤其对患者伦纳德·洛（罗伯特·德尼罗 Robert De Niro）效果尤为明显。但令人意外的是，患者们在苏醒后不久，又纷纷出现了病情恶化的趋势…… 本片获奥斯卡最佳影片、最佳男主角（罗伯特·德尼罗）和最佳改编剧本奖提名，并获金球奖剧情类影片最佳男主角提名（罗宾·威廉姆斯）。
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Hospital physician June Lowe and successful author Rick Lowe have a seemingly perfect marriage, the one sticking point between them being the issue of children. Rick wants June to give up her career so that they can start a family, and while June is not averse to the notion of children, not only does she not want to give up her career but expand into writing herself, she not understanding why Rick couldn'tshouldn't be the primary caregiver anyway in already working from home. In the process, June feels like Rick totally dismisses her feelings. When Rick receives a blackmail letter for something he totally denies as truth, June gets implicated in a double homicide. June quickly realizes that Rick is trying to frame her, he the actual murderer. As June needs to evade both Rick and the police and has no one to confide in, including her generally loving sister Maggie Porter who believes the accusations of she being a murderer, June not only has to discover why Rick killed the two victims but why he is trying to frame her. When she believes she's discovered what's going on, June enters a dangerous cat and mouse game with Rick, it not always clear who is the cat and who is the mouse.—Huggo
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